Iodine triethylene glycol [Iodtriethylenglicolum (ITEG)-A] is a antimicrobial medical product in a form of solution, which contains following substanses as active: iodium - 4%, potassium iodide, potassium iodate, and triethyleneglycol and hydrochloric acid as auxiliary ingredients. Iodine triethylene glycol (ITEG)-A is a homogeneous liquid, dark-red in color with iodine odor.
|Authored by: L.I. Iakhaev, M.L. Iakhaev
(Joint-stock company factory «Veterinary medicines», Gus-Khrustalny, Vladimir Region)
Iodine triethylene glycol (ITEG)-A is successfully used for the treatment of respiratory diseases of poultry. Directions for the Iodine triethylene glycol (ITEG)-A usage approved by E.A. Nepoklonov, Deputy Director of the Federal Service for Veterinary and Phytosanitary Surveillance on June 30th, 2005 (Registration Certificate number ПВР-2-1.5/01512) exist.
It is well known that besides antimicrobial activity iodine-containing preparations mainly trigger reflexive expectorant effect, speeding pathological mucus evacuation up. In the book "Aerosols in veterinarian medicine" written by V.S. Iarnykh in 1972, it is indicated about triethylene glycol high activity against different kinds of bacterias and viruses, including staphylococcus, pneumococcus and many other viruses.
Iodine triethylene glycol is used for the treatment of respiratory diseases of poultry.
Aerosol spraying technique, which allows to process the greater animal concentration premises without significant workforce inputs is one of the most promising methods of Iodine triethylene usage. Thereby, drug consumption for one processing track reduces in several times. Comparing with traditional processing methods, labor input of work to be performed also reduces. The costs involved in drug consumption for aerosol production are fully covered due to safety increasing, weight gain and final accretion of young stock.
Experience shows that antimicrobial preparations in aerosol form can be used at all technological steps from the first days of chick's life and respectively from the first or second month of prenursery pig's life.
As B.F. Bessarabov and V.I. Polianinov (2005) indicated, aerosol medicinal preparations are particularly effective for the treatment and prevention of respiratory diseases, because in these cases they are injected the same way as pathogenic agents are usually spread into animal body. As a result, rapid contact of preparation with the pathogenic agents in primary disease site is provided (B.F. Bessarabov, A.B. Baidevliatov, 1992). It is determined that the preparation is sorbed on mucous membrane in 3-6 times more than in the case of intramuscular usage and in 8-11 times more than in the case of oral usage. Drug concentration is in 2-3.5 times higher than in the case of intramuscular injections and in 15-20 times higher than in the case of oral injections.
Antimicrobial preparations in aerosol form are absorbed through the lungs, alveolar surfaces of which are easy permeable, especially for micro-atomized and gaseous substances.
Penetration depth of aerosol particles into the respiratory system of animals depends on dispersity degree of the particles: the larger the particles, the more of them stay on the upper respiratory track. In cases of bronchus and lungs diseases, the aerosol particles size should be 1-10 micrometers; the particles less than 0.2-0.3 micrometers are therapeutically inefficient. The particles more than 10 micrometers are settled in epipharynx and trachea (B.F. Bessarabov, V.I. Polianinov, 2005).
Having analyzed respiratory swine diseases, B.G. Orliankin and others (2006) announce that most of the time, the diseases take place as mixed viral and bacterial infections. Comprehensive vaccines are required for its prevention.
Agreeing to this approach for the problem, we believe that, above all else, it is effectually to recommend aerosol processing of swine young stock with Iodine triethylene glycol.
Preliminary in vitro antimicrobial activity analysis has showed that Iodine triethylene glycol triggers colibacillus death in 1% concentration at 0.5 hour of exposure, and aurococcus death in 20% concentration at the same time of exposure.
Suspension expertise showed that bactericidal Iodine triethylene glycol dilution against colibacillus in absence of protein at 10 minutes of exposure amounts 2% and at 60 minutes of exposure amounts 2.0% and 2.5% respectively.
In the same expertise conditions without protein defence at 10 and 60 minutes of exposure the bactericidal dilution of the preparation against aurococcus amounts 3.5% and 3.0% respectively; the results with protein defence are 3.5% and 3.0% respectively.
High-level preparation efficiency was identified in further experiments in production Iodine triethylene glycol usage in cases of respiratory diseases of pigs. The experiments were conducted in different households in Bashkiria, Udmurtia, Vladimir and Volgograd Regions. The preparation was used in animal presence in 50% concentration in a dose of 2.0 ml/1 m3 at 30 minutes of exposure.
The preparation was sprayed by aerosol generators when ventilation is off in three day cycles with an interval of 2-3 days 3-4 cycles in total in different age period depending on the time of disease. Cough, stunting and food refusal of pigs were indicated before the usage of Iodine triethylene glycol. Mortality level amounted to 25%. Illness frequency of pigs significantly declined and mortality level was reduced by 15% after the usage of Iodine triethylene glycol.
Conclusion. Iodine triethylene glycol has clearly expressed health-promoting benefits in the cases of respiratory diseases in pigs and poultry.